Millipore Sigma Vibrant Logo

506418 µ-δ Opiod Receptor Agonist, CYM51010 - CAS 1069498-96-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: CID23723457, CYM-51010, ML335, Opiod Receptor Ligand, Ethyl-1-(4-acetamidobenzyl)-4-phenethylpiperidine-4-carboxylate, Ethyl-1-(4-acetamidobenzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate, Ethyl 1-(4-(acetylamino)benzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate

Primary Target: µOR-δOR-heteromer
506418
查看价格及供货情况

概述

Replacement Information

重要规格表

CAS #Empirical Formula
1069498-96-9C₂₅H₃₂N₂O₃

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
5.06418.0001
正在查询供货情况......
—
目前缺货 目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余：另行通知
      其余：另行通知
      另行通知
      联系客户服务
      Contact Customer Service

      		 玻璃瓶 10 mg
      正在检索价格......
      无法检索价格。
      最小订购数量为倍数
      Maximum Quantity is
      以订单确认为准 更多信息
      您节约了 ()。
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable, blood-brain barrier permeant, non-toxic phenethylpiperidine compound that binds reversibly and with high affinity to the μOR-δOR-heteromer. Exhibits a robust β-arrestin recruitment activity (EC50 = 8.3 µM; Emax = 1,197% over basal), which is at least two to three-fold higher than that obtained with μβgalOR (EC50 = 1.8 µM; Emax = 557%) or δβgalOR (EC50 = 2.7 µM; Emax = 423%) alone. Induces a strong increase in [35S]GTPγS binding (EC50 = 54, 210, and 300 nM; and Emax (% basal) = 168, 138 and 113 for with μβgalOR-δOR, μβgalOR and δβgalOR, respectively). Potentiates antinociceptive activity similar to morphine (10 mg/kg, s.c. in a tail-flick assay) with less side effects and dependency. However, chronic administration of CYM51010 results in reduced antinociceptive tolerance compared with morphine.
      Catalogue Number506418
      Brand Family Calbiochem®
      SynonymsCID23723457, CYM-51010, ML335, Opiod Receptor Ligand, Ethyl-1-(4-acetamidobenzyl)-4-phenethylpiperidine-4-carboxylate, Ethyl-1-(4-acetamidobenzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate, Ethyl 1-(4-(acetylamino)benzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate
      References
      ReferencesGomes, I., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 12072.
      Product Information
      CAS number1069498-96-9
      FormWhite solid
      Hill FormulaC₂₅H₃₂N₂O₃
      Chemical formulaC₂₅H₃₂N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetµOR-δOR-heteromer
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      5.06418.0001 04055977242720

      Documentation

      µ-δ Opiod Receptor Agonist, CYM51010 - CAS 1069498-96-9 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      参考

      参考信息概述
      Gomes, I., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 12072.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-December-2013 JSW
      SynonymsCID23723457, CYM-51010, ML335, Opiod Receptor Ligand, Ethyl-1-(4-acetamidobenzyl)-4-phenethylpiperidine-4-carboxylate, Ethyl-1-(4-acetamidobenzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate, Ethyl 1-(4-(acetylamino)benzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate
      DescriptionA cell-permeable, blood-brain barrier permeant, non-toxic phenethylpiperidine compound that binds reversibly and with high affinity to the μOR-δOR-heteromer. Exhibits a robust β-arrestin recruitment activity (EC50 = 8.3 µM; Emax = 1,197% over basal), which is at least two to three-fold higher than that obtained with μβgalOR (EC50 = 1.8 µM; Emax = 557%) or δβgalOR (EC50 = 2.7 µM; Emax = 423%) alone. Induces a strong increase in [35S]GTPγS binding (EC50 = 54, 210, and 300 nM; and Emax (% basal) = 168, 138 and 113 for with μβgalOR-δOR, μβgalOR and δβgalOR, respectively). Potentiates antinociceptive activity similar to morphine (10 mg/kg, s.c. in a tail-flick assay) with less side effects and dependency. However, chronic administration of CYM51010 results in reduced antinociceptive tolerance compared with morphine.
      FormWhite solid
      CAS number1069498-96-9
      Chemical formulaC₂₅H₃₂N₂O₃
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGomes, I., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 12072.