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565763 Sigma-Aldrichγ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem

The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide

Primary Target: Aβ₄₂ production

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
287196-57-0	C₁₆H₂₂FNO₂S

价格及供货情况

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Description
Overview	Cell permeable. Potently inhibits Aβ₄₂ production (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.
Catalogue Number	565763
Brand Family	Calbiochem®
Synonyms	1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide

References
References	Rishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.

Product Information
CAS number	287196-57-0
ATP Competitive	N
Form	White solid
Hill Formula	C₁₆H₂₂FNO₂S
Chemical formula	C₁₆H₂₂FNO₂S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Aβ₄₂ production
Primary Target IC<sub>50</sub>	1.8 µM against Aβ42 production
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565763-5MGCN	04055977267723

Documentation

γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem 分析证书

标题	批号
565763	输入批号

参考

参考信息概述
Rishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-April-2011 RFH
Synonyms	1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
Description	A potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ₄₂ (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APP_Sα, but no change in secreted APP_Sβ, indicating a specific inhibition of γ-secretase activity.
Form	White solid
CAS number	287196-57-0
Chemical formula	C₁₆H₂₂FNO₂S
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (200 mg/ml)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Rishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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