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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

118415 Sigma-AldrichADP-HPD, Dihydrate, Ammonium Salt - Calbiochem

ADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
技术信息
Data Sheet

同义词: Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄

Primary Target: PARG

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概述

Replacement Information

重要规格表

Empirical Formula
C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
118415-1SETCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	1 set	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
118415-60UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	60 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Note: 1 set = 5 x 60 µg.
Overview	Note: 1 set = 5 x 60 µg
Catalogue Number	118415
Brand Family	Calbiochem®
Synonyms	Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄

References
References	Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886. Slama, J.T., et al. 1995. J. Med. Chem. 38, 389. Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.

Product Information
ATP Competitive	N
Form	White lyophilized solid
Hill Formula	C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
Chemical formula	C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	ADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).

Biological Information
Primary Target	PARG
Primary Target IC<sub>50</sub>	120 nM against poly(ADP-ribose) glycohydrolase (PARG)
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
118415-1SETCN	04055977224009
118415-60UGCN	07790788047887

Documentation

ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem 分析证书

标题	批号
118415	输入批号

参考

参考信息概述
Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886. Slama, J.T., et al. 1995. J. Med. Chem. 38, 389. Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.

技术信息

标题
Data Sheet - 118415 Envirocheck Contact plates VRB agar (Violet Red Bile Agar)

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-October-2007 RFH
Synonyms	Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
Description	An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC₅₀ = 120 nM) vs. ADP-ribose (IC₅₀ = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.
Form	White lyophilized solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
Structure formula
Purity	≥95% by HPLC
Solubility	H₂O (5 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
Toxicity	Standard Handling
References	Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886. Slama, J.T., et al. 1995. J. Med. Chem. 38, 389. Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Poly(ADP-ribose) Polymerase (PARP) and Poly(ADP-ribose) Glycohydrolase (PARG) Inhibitors

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