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116816 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem

A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Rp-8-Br-cAMPS, Na, PKA Inhibitor VI

Primary Target: PKA 1
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      概述

      Replacement Information

      重要规格表

      Empirical Formula
      C₁₀H₁₀BrN₅O₅PS · Na
      Description
      OverviewA potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I. More lipophilic than cAMP antagonist Rp-cAMPS (Cat. No. 116814).
      Note: 5 µmol = 2.23 mg.
      Catalogue Number116816
      Brand Family Calbiochem®
      SynonymsRp-8-Br-cAMPS, Na, PKA Inhibitor VI
      References
      ReferencesCalaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
      Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₀H₁₀BrN₅O₅PS · Na
      Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKA 1
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      116816 0

      Documentation

      Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem 分析证书

      标题批号
      116816

      参考

      参考信息概述
      Calaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
      Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.

      小册子

      标题
      Inhibitor Sourcebook 3rd Edition

      引用

      标题
    • Ralf Gutzmer, et al. (2005) Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. Journal of Immunology 5224-5232.
      		•
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-January-2010 RFH
      SynonymsRp-8-Br-cAMPS, Na, PKA Inhibitor VI
      DescriptionCell-permeable, potent, reversible, and metabolically stable antagonist of cAMP that is resistant to the action of mammalian cyclic nucleotide phosphodiesterases. Rp-8-Br-cAMPS is more lipophilic as compared to 8-Br-cAMP and Rp-cAMPS. In contrast to other common ATP-site inhibitors or to its parent compound Rp-cAMPS, Rp-8-Br-cAMPS discriminates between both isozymes of protein kinase A, preferring type I, thus providing additional selectivity. By occupying cAMP binding sites, prevents dissociation and activation of the kinase holoenzyme. λ = 264 nm (H2O, pH 7.0); εmax 17,000 M-1cm-1.
      FormLyophilized
      Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (40 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCalaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
      Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.
      Citation
    • Ralf Gutzmer, et al. (2005) Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. Journal of Immunology 5224-5232.
      		•