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129876 Sigma-AldrichAmiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem

An inhibitor of angiogenesis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I

Primary Target: capillary morphogenesis

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
2016-88-8	C₆H₈ClN₇O • HCl

价格及供货情况

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Description
Overview	An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na⁺ entry and Na⁺,K⁺-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.
Catalogue Number	129876
Brand Family	Calbiochem®
Synonyms	Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I

References
References	Knoll, A., et al. 1999. Microvasc. Res. 58, 1. Swiercz, R., et al. 1999. Oncol. Rep. 6, 523. Moran, A., et al. 1995. Am. J. Physiol. 268, C350. Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245. Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215. Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101. Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.

References

Knoll, A., et al. 1999. Microvasc. Res. 58, 1.
Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.

Product Information
CAS number	2016-88-8
ATP Competitive	N
Form	Off-white to yellow solid
Hill Formula	C₆H₈ClN₇O • HCl
Chemical formula	C₆H₈ClN₇O • HCl
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	capillary morphogenesis
Primary Target IC<sub>50</sub>	130 µM inhibiting capillary morphogenesis completely and reversibly
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	UQ2275500

Safety Information
R Phrase	R: 25 Toxic if swallowed.
S Phrase	S: 45-36 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Toxic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+15°C to +30°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
129876-100MGCN	04055977222289

Documentation

Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem 分析证书

标题	批号
129876	输入批号

参考

参考信息概述
Knoll, A., et al. 1999. Microvasc. Res. 58, 1. Swiercz, R., et al. 1999. Oncol. Rep. 6, 523. Moran, A., et al. 1995. Am. J. Physiol. 268, C350. Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245. Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215. Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101. Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	20-April-2009 JSW
Synonyms	Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
Description	An inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na⁺/H⁺ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.
Form	Off-white to yellow solid
CAS number	2016-88-8
RTECS	UQ2275500
Chemical formula	C₆H₈ClN₇O • HCl
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml) or H₂O (2.5 mg/ml)
Storage	Protect from light +15°C to +30°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
Toxicity	Toxic
Merck USA index	14, 406
References	Knoll, A., et al. 1999. Microvasc. Res. 58, 1. Swiercz, R., et al. 1999. Oncol. Rep. 6, 523. Moran, A., et al. 1995. Am. J. Physiol. 268, C350. Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245. Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215. Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101. Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > ATPase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Plasminogen Activator Inhibitors

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