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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

ABC482 Sigma-AldrichAnti-ADE2 Antibody/SAICAR synthetase

This Anti-ADE2 antibody is validated for use in Western Blotting for the detection of ADE2.

Anti-ADE2 Antibody/SAICAR synthetase MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PAICS, ADE2, AIRC, PAIS UniProt Number: P22234

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABC482
Description	Anti-ADE2 Antibody/SAICAR synthetase
Alternate Names	Multifunctional protein ADE2 Phosphoribosylaminoimidazole-succinocarboxamide synthase SAICAR synthetase Phosphoribosylaminoimidazole carboxylase AIR carboxylase AIRC
Background Information	Multifunctional protein ADE2, which is encoded by the gene name PAICS, ADE2, AIRC, PAIS, is a member of the SAICAR synthetase family and the AIR carboxylase family. Multifunctional protein ADE2 includes the following two domains: Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase), and Phosphoribosylaminoimidazole carboxylase (AIR carboxylase/ AIRC). ADE2 is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. ADE2 is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for ADE2. ADE2/ PAICS (phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase) is a protein-coding gene. Diseases associated with ADE2 include androgen insensitivity syndrome, and pseudohermaphroditism, and among its related super-pathways are Metabolic pathways and Purine metabolism.

References

Product Information
Format	Affinity Purified
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-ADE2 antibody is validated for use in Western Blotting for the detection of ADE2.
Key Applications	Western Blotting

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to human ADE2/SAICAR synthetase.
Epitope	SAICAR synthetase
Concentration	Please refer to lot specific datasheet.
Host	Rabbit
Species Reactivity	Human
Species Reactivity Note	Human. Predicted to react with Rat, Mouse, Bovine, Feline, Canine, Porcine, Chimpanzee, and Rhesus Monkey based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_001072992
Gene Symbol	PAICS ADE2 AIRC PAIS
Purification Method	Affinity Purfied
UniProt Number	P22234
Molecular Weight	~47 kDa observed. Uncharacterized band(s) may appear in some lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected ADE2/SAICAR synthetase in 10 µg of TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABC482	04055977122282

Documentation

Anti-ADE2 Antibody/SAICAR synthetase MSDS

职位
物料安全数据表 (MSDS)

Anti-ADE2 Antibody/SAICAR synthetase 分析证书

标题	批号
Anti-ADE2/SAICAR synthetase - 4261040	4261040
Anti-ADE2/SAICAR synthetase Polyclonal Antibody -Q2490403	Q2490403

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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