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05-1134 Sigma-AldrichAnti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1

Detect Fibroblast Growth Factor Receptor 1 using this Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1 validated for use in WB, IP, IH(P), ELISA.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: CD331, CEK, EC 2.7.10.1, FGFBR, FGFR-1, FLG, FLJ99988, FLT2, H2, H3, H4, H5, HBGFR, KAL2, N-SAM , OGD, OTTHUMP00000190874, OTTHUMP00000190878 , OTTHUMP00000190879, OTTHUMP00000190881, bFGF-R, c-fgr , BFGFR UniProt Number: P11362

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概述

Replacement Information

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R, Ch, B	WB, IP, IH(P), ELISA	M	Purified	Monoclonal Antibody

Description
Catalogue Number	05-1134
Replaces	MAB125
Description	Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1
Alternate Names	CD331 antigen Fms-like tyrosine kinase 2 basic fibroblast growth factor receptor 1 fibroblast growth factor receptor 1 fms-related tyrosine kinase 2 heparin-binding growth factor receptor hydroxyaryl-protein kinase soluble FGFR1 variant 1 soluble FGFR1 variant 2
Background Information	The fibroblast growth factor receptors are members of the tyrosine kinase superfamily and consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. (Ornitz, DM. and Itoh, N) Monoclonal antibodies against the high affinity tyrosine kinase Fibroblast Growth Factor (FGF) receptor may help define receptor epitopes involved in FGF binding and signal transduction which mediate coronary and tumor angiogenesis. (Venkateswaran, S., et al).

References

Product Information
Format	Purified
Control	NIH/3T3 cell lysate
Presentation	Purified mouse monoclonal IgM in 0.015 M potassium phosphate buffer containing 0.15 M NaCl, 0.1% sodium azide, pH 7.20.
Quality Level	MQ100

Applications
Application	Detect Fibroblast Growth Factor Receptor 1 using this Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1 validated for use in WB, IP, IH(P), ELISA.
Key Applications	Western Blotting Immunoprecipitation Immunohistochemistry (Paraffin) ELISA
Application Notes	Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH(P) (Venkateswaran, S., et al)

Biological Information
Immunogen	FGF Receptor purified from bovine coronary venular endothelial cells.
Epitope	Extracellular
Clone	VBS1
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	This antibody recognizes the extracellular ligand-binding domain of Fibroblast Growth Factor Receptor 1.
Isotype	IgM
Species Reactivity	Human Mouse Rat Chicken Bovine
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001103677.1
Gene Symbol	CD331 CEK EC 2.7.10.1 FGFBR FGFR-1 FLG FLJ99988 FLT2 H2 H3 H4 H5 HBGFR KAL2 N-SAM OGD OTTHUMP00000190874 OTTHUMP00000190878 OTTHUMP00000190879 OTTHUMP00000190881 bFGF-R c-fgr BFGFR
UniProt Number	P11362
UniProt Summary	FUNCTION: Receptor for basic fibroblast growth factor. Receptor for FGF23 in the presence of KL By similarity. A shorter form of the receptor could be a receptor for FGF1 (aFGF). CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT STRUCTURE: Interacts with SHB. Interacts with KLB By similarity. Interacts with KL and FGF23 By similarity. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. PTM: Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor. INVOLVEMENTI IN DISEASE: Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly. Defects in FGFR1 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous. Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant. Defects in FGFR1 are the cause of non-syndromic trigonocephaly [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome. A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with CEP110. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
Molecular Weight	~92 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in NIH/3T3 cell lysate. Western Blotting Analysis: 0.78 µg/mL of this antibody detected Fibroblast Growth Factor Receptor 1 in 10 µg of NIH/3T3 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
05-1134	04053252271151

Documentation

Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1 MSDS

职位
物料安全数据表 (MSDS)

Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1 分析证书

标题	批号
Anti-Fibroblast Growth Factor -2688495	2688495
Anti-Fibroblast Growth Factor -2814746	2814746
Anti-Fibroblast Growth Factor Receptor 1, clone VBS1	3079110
Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - 2382645	2382645
Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - 2477978	2477978
Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - NG1809963	NG1809963
Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - NG1840148	NG1840148
Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - NG1853793	NG1853793
Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 - NRG1695399	NRG1695399
Anti-Fibroblast Growth Factor Receptor 1, clone VBS1 -2564848	2564848

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种类

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