数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

AB10532 Sigma-AldrichAnti-GABA(A) receptor subunit gamma-2 Antibody

This Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GEFSP3, CAE2, ECA2, GABRG2 UniProt Number: P18508

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, H	WB	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	AB10532
Description	Anti-GABA(A) receptor subunit gamma-2 Antibody
Alternate Names	gamma-aminobutyric acid (GABA) A receptor, gamma 2 gamma-aminobutyric acid A receptor, gamma 2 GABA(A) receptor subunit gamma-2
Background Information	GABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.

References

Product Information
Format	Serum
Control	PC12 cell lysate
Presentation	Rabbit polyclonal serum containing 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2.
Key Applications	Western Blotting

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to rat GABA(A) receptor subunit gamma-2.
Host	Rabbit
Specificity	This antibody recognizes GABA(A) receptor subunit gamma-2.
Species Reactivity	Rat Human
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_899156
Entrez Gene Summary	Subunit of GABA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD].
Gene Symbol	GEFSP3 CAE2 ECA2 GABRG2
Purification Method	Unpurified
UniProt Number	P18508
UniProt Summary	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. SUBUNIT STRUCTURE: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. SUBCELLULAR LOCATION: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. PTM: Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability (By similarity). MISCELLANEOUS: This subunit carries the benzodiazepine binding site. SEQUENCE SIMLARITIES: Belongs to the ligand-gated ionic channel (TC 1.A.9) family. (View classification)
Molecular Weight	~60 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in PC12 cell lysate. Western Blot Analysis: 1:1,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 on 10 µg of PC12 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
AB10532	04053252478802

Documentation

Anti-GABA(A) receptor subunit gamma-2 Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-GABA(A) receptor subunit gamma-2 Antibody 分析证书

标题	批号
Anti-GABA(A) receptor subunit -2550894	2550894
Anti-GABA(A) receptor subunit gamma-2 - 2445044	2445044
Anti-GABA(A) receptor subunit gamma-2 - 2039821	2039821
Anti-GABA(A) receptor subunit gamma-2 - 3691429	3691429
Anti-GABA(A) receptor subunit gamma-2 - 3808722	3808722
Anti-GABA(A) receptor subunit gamma-2 - NG1881286	NG1881286
Anti-GABA(A) receptor subunit gamma-2 - NRG1781528	NRG1781528

Related Products

产品目录编号

描述

MABN263

Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8

显示价格及库存情况

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

此产品已添加到您的购物车。