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MABT187 Sigma-AldrichAnti-Kindlin-3 Antibody, clone 181A

Anti-Kindlin-3 Antibody, clone 181A is an antibody against Kindlin-3 for use in Western Blotting.

Anti-Kindlin-3 Antibody, clone 181A MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: FERMT3, KIND3, MIG2B, URP2 UniProt Number: Q86UX7

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概述

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	R	Purified	Monoclonal Antibody

Description
Catalogue Number	MABT187
Description	Anti-Kindlin-3 Antibody, clone 181A
Alternate Names	Fermitin family homolog 3 Kindlin-3 MIG2-like protein Unc-112-related protein 2
Background Information	Kindlin-3 is an intracellular protein encoded by the FERMT3 gene and which binds directly to the β chain cytoplasmic tail of integrin in hematopoietic cells. This protein belongs to a family of adhesion plaque proteins, of which there are three members, which act to activate integrins. Kindlin-3 differs from Kindlins-1 and -2 in that its expression is restricted to hematopoietic systems and is especially high in spleen and megakaryocytes. It is a necessary component for integrin activation and for platelet aggregation. Mutations in FERMT3 and consequently to the encoding of Kindlin-3 protein are causal to LAD-I variant syndrome, an uncommon genetic disorder in which integrin adhesive functions on platelets and leukocytes are disrupted.

References

Product Information
Format	Purified
Control	K562 cell lysate
Presentation	Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Kindlin-3 Antibody, clone 181A is an antibody against Kindlin-3 for use in Western Blotting.
Key Applications	Western Blotting

Biological Information
Immunogen	His-tagged recombinant protein corresponding to human Kindlin-3.
Clone	181A
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rat
Isotype	IgG2aκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_113659
Gene Symbol	FERMT3 KIND3 MIG2B URP2
Purification Method	Protein G Purified
UniProt Number	Q86UX7
Molecular Weight	~76 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in K562 cell lysate. Western Blot Analysis: A 1:1,000 dilution of this antibody detected Kindlin-3 in 10 µg of K562 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABT187	04053252649622

Documentation

Anti-Kindlin-3 Antibody, clone 181A MSDS

职位
物料安全数据表 (MSDS)

Anti-Kindlin-3 Antibody, clone 181A 分析证书

标题	批号
Anti-Kindlin-3, clone 181A	2480966
Anti-Kindlin-3, clone 181A - 2454743	2454743
Anti-Kindlin-3, clone 181A - 2462915	2462915
Anti-Kindlin-3, clone 181A - 3225743	3225743
Anti-Kindlin-3, clone 181A - 3697336	3697336
Anti-Kindlin-3, clone 181A - Q2050288	Q2050288
Anti-Kindlin-3, clone 181A -2745867	2745867
Anti-Kindlin-3, clone 181A -2757861	2757861
Anti-Kindlin-3, clone 181A Monoclonal Antibody	2922354

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种类

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