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ABE558 Sigma-AldrichAnti-Ku70 Protein Antibody

Detect Ku70 Protein using this rabbit polyclonal antibody, Anti-Ku70 Protein Antibody validated for use in western blotting, IP & IHC (Paraffin).

Anti-Ku70 Protein Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: XRCC6, G22P1 UniProt Number: P12956

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IP, IH(P)	Rb	Purified	Polyclonal Antibody

Description
Catalogue Number	ABE558
Replaces	AB1358
Description	Anti-Ku70 Protein Antibody
Alternate Names	X-ray repair cross-complementing protein 6 5'-deoxyribose-5-phosphate lyase Ku70 5'-dRP lyase Ku70 70 kDa subunit of Ku antigen ATP-dependent DNA helicase 2 subunit 1 ATP-dependent DNA helicase II 70 kDa subunit CTC box-binding factor 75 kDa subunit CTC75 CTCBF DNA repair protein XRCC6 Lupus Ku autoantigen protein p70 Ku70 Thyroid-lupus autoantigen TLAA X-ray repair complementing defective repair in Chinese hamster cells 6
Background Information	Lupus Ku autoantigen protein p70 (Ku70) is also known as X-ray repair cross-complementing protein 6 (XRCC6), 5'-dRP lyase Ku70, CTC box-binding factor 75 kDa subunit (CTC75, CTCBF) or Thyroid-lupus autoantigen (TLAA). Ku70 is a single stranded DNA-dependent ATP-dependent helicase that plays a role in chromosome translocation and DNA non-homologous end joining (NHEJ) required for double-strand break repair and recombination. The XRCC5/6 (Ku80/Ku70) dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK, and that dimer, together with APEX1, acts as a negative regulator of transcription. Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to XRCC5 (Ku80) and XRCC6 (Ku70).

References

Product Information
Format	Purified
Control	HeLa cell lysate
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect Ku70 Protein using this rabbit polyclonal antibody, Anti-Ku70 Protein Antibody validated for use in western blotting, IP & IHC (Paraffin).
Key Applications	Western Blotting Immunoprecipitation Immunohistochemistry (Paraffin)
Application Notes	Immunoprecipitation Analysis: A representative lot immunoprecipitated Ku70 Protein in 0.5 mg of HeLa cell lysate. Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Ku70 Protein in human prostate carcinoma cells and human testis tissue.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to human Ku70 Protein near N-Terminus.
Epitope	Near N-Terminus
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	This antibody recognizes Ku70 Protein near N-Terminus.
Species Reactivity	Human
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_001460
Gene Symbol	XRCC6 G22P1
Purification Method	Protein A Purfied
UniProt Number	P12956
Molecular Weight	~70 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in HeLa cell lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected Ku70 Protein in 10 µg of HeLa cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABE558	04053252906404

Documentation

Anti-Ku70 Protein Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-Ku70 Protein Antibody 分析证书

标题	批号
Anti-Ku70 Protein - 2561792	2561792
Anti-Ku70 Protein - 3593174	3593174
Anti-Ku70 Protein - Q2187163	Q2187163
Anti-Ku70 Protein Polyclonal Antibody	3775420

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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