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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABN367 Sigma-AldrichAnti-SV2C Antibody, clone 4C8.1

Anti-SV2C Antibody, clone 4C8.1 is a highly specific mouse monoclonal antibody, that targets SV2C & has been tested in western blotting & IHC.

Anti-SV2C Antibody, clone 4C8.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
小册子

Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: SV2C, KIAA1054 UniProt Number: Q496J9

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M, H	WB, IHC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN367
Description	Anti-SV2C Antibody, clone 4C8.1
Alternate Names	Synaptic vesicle glycoprotein 2C SV2C
Background Information	The protein named Synaptic vesicle glycoprotein 2C (SV2C) and encoded by the human name named SV2C/KAA1054 is glycosylated membrane bound protein important in vesicle secretion. SV2C is part of the major facilitator superfamily of vesicle movement and fusion proteins and is particularly important is vesicle fusion by maintaining a readily releasable pool of secretory granules. Expressed in neural and endocrine cells primarily, SV2C is important for neurotransmission and hormone release. SV2C is enriched in small synaptic vesicles and adrenal microsomes but it is not present in chromaffin granules but is found in insulin granules and microvesicles in the pancreas. In the brain SV2C, in contrast to SV2A and SV2B, expression is restricted to certain regions. High levels of SV2C are found primarily in phylogenetically old brain regions such as the pallidum, the substantia nigra, the midbrain, the brainstem and the olfactory bulb, but SV2C is undetectable in the cerebral cortex and the hippocampus, and found at low levels in the cerebellar cortex. Recent research though also demonstrates that SV2C plays an important role in normal operation of the basal ganglia network and SV2C could also be involved in system adaptation during basal ganglia pathology.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-SV2C Antibody, clone 4C8.1 is a highly specific mouse monoclonal antibody, that targets SV2C & has been tested in western blotting & IHC.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SV2C in human cerebellum and human thalamus tissue.

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to the cytoplasmic domain of human SV2C.
Epitope	Cytoplasmic domain
Clone	4C8.1
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Mouse Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_055794
Gene Symbol	SV2C KIAA1054
Purification Method	Protein G Purified
UniProt Number	Q496J9
Molecular Weight	~82 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in mouse brain tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected SV2C in 200 µg of mouse brain tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN367	04053252934001

Documentation

Anti-SV2C Antibody, clone 4C8.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-SV2C Antibody, clone 4C8.1 分析证书

标题	批号
Anti-SV2C, clone 4C8.1 - 3425571	3425571
Anti-SV2C, clone 4C8.1 - 3597303	3597303
Anti-SV2C, clone 4C8.1 - 3842854	3842854
Anti-SV2C, clone 4C8.1 - 4087589	4087589
Anti-SV2C, clone 4C8.1 - 4194303	4194303
Anti-SV2C, clone 4C8.1 - Q2301465	Q2301465
Anti-SV2C, clone 4C8.1 Monoclonal Antibody	3123181

小册子

标题
New Products Flyer- Feb 2014 - Vol 1

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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