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ABE434 Sigma-AldrichAnti-TIF1-alpha Antibody

Detect TIF1α using this rabbit polyclonal antibody, Anti-TIF1-alpha Antibody validated for use in western blotting & ICC.

Anti-TIF1-alpha Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: TRIM24, RNF82, TIF1, TIF1A UniProt Number: O15164

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, ICC	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABE434
Description	Anti-TIF1-alpha Antibody
Alternate Names	Transcription intermediary factor 1-alpha E3 ubiquitin-protein ligase TRIM24 RING finger protein 82 Tripartite motif-containing protein 24
Background Information	Transcription intermediary factor 1-alpha (TIF1-alpha) is also called E3 ubiquitin-protein ligase TRIM24, RING finger protein 82, and Tripartite motif-containing protein 24. TIF1-alpha is a transcriptional coactivator that interacts with chromatin depending on histone H3 modifications, with the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). TIF1-alpha has E3 protein-ubiquitin ligase activity, helps regulate cell proliferation and apoptosis and up-regulates transcription activation. Aberrant TIF1-alpha can cause thyroid papillary carcinoma (TPC) and is up-regulated in some breast cancers.

References

Product Information
Format	Affinity Purified
Control	HeLa cell lysate
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect TIF1α using this rabbit polyclonal antibody, Anti-TIF1-alpha Antibody validated for use in western blotting & ICC.
Key Applications	Western Blotting Immunocytochemistry
Application Notes	Immunocytochemistry Analysis: A 1:50 dilution from a represenative lot detected TIF1-alpha in HeLa cells.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to the C-terminus of the Nuclear Receptor Binding Site (NRBS) of human TIF1-alpha.
Epitope	C-terminus of the Nuclear Receptor Binding Site (NRBS)
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	This antibody recognizes the C-terminus of the Nuclear Receptor Binding Site (NRBS) of TIF1-alpha.
Species Reactivity	Human Mouse
Species Reactivity Note	Demonstrated to react with Human and Mouse. Predicted to react with Rhesus Macaque based on 100% sequence homology. Other homologies: Rat (93% sequence homology).
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_056989
Gene Symbol	TRIM24 RNF82 TIF1 TIF1A
Purification Method	Affinity Purfied
UniProt Number	O15164
Molecular Weight	~140 kDa observed. Uniprot descrives 2 isoforms at ~117 kDa and ~113 kDa due to alternative splicing. This protein has been observed at ~140 kDa (Gunawardena, H., et al. (2008). Rheumatology (Oxford). 47(3):324-328.).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in HeLa cell lysate. Western Blotting Analysis: 0.1 µg/mL of this antibody detected TIF1-alpha in 10 µg of HeLa cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABE434	04053252914676

Documentation

Anti-TIF1-alpha Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-TIF1-alpha Antibody 分析证书

标题	批号
Anti-TIF1-alpha - Q2208852	Q2208852

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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