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06-1425 Sigma-AldrichAnti-phospho-TAK1 (Ser412) Antibody

Detect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.

Anti-phospho-TAK1 (Ser412) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Signaling Research Sub-Category: MAP Kinases Gene Symbol: MAP3K7, TAK1 UniProt Number: O43318

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	06-1425
Description	Anti-phospho-TAK1 (Ser412) Antibody
Alternate Names	Mitogen-activated protein kinase kinase kinase 7 Transforming growth factor-beta-activated kinase 1 TGF-beta-activated kinase 1
Background Information	TAK1 MAPKKK is activated by TAB1 to transform growth factor-beta (TGF-beta) signaling. TAK1 can also associate with TAB1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. TAK1 has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.

References

Product Information
Format	Affinity Purified
Control	Lambda phosphatase treated and untreated Murine RAW cell lysates
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to human TAK1 phosphorylated at Ser412.
Epitope	Phosphorylated Ser412
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	This antibody recognizes TAK1 phosphorylated at Ser412.
Species Reactivity	Human Mouse
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_663306
Entrez Gene Summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
Gene Symbol	MAP3K7 TAK1
Modifications	Phosphorylation
Purification Method	Affinity Purfied
UniProt Number	O43318
UniProt Summary	FUNCTION: Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway. COFACTOR: Magnesium. SIZE: 606 amino acids; 67196 Da SUBUNIT: Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L. PTM: Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. & Contains 1 protein kinase domain.
Molecular Weight	~70 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in lambda phosphatase treated and untreated Murine RAW cell lysates. Western Blot Analysis: 1 µg/mL of this antibody detected TAK1 on 10 µg of lambda phosphatase treated and untreated Murine RAW cell lysates.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	200 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
06-1425	04053252630972

Documentation

Anti-phospho-TAK1 (Ser412) Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-phospho-TAK1 (Ser412) Antibody 分析证书

标题	批号
Anti-phospho-TAK1 (Ser412) - 2216894	2216894
Anti-phospho-TAK1 (Ser412) - 2324676	2324676
Anti-phospho-TAK1 (Ser412) - 3185657	3185657
Anti-phospho-TAK1 (Ser412) - 3728328	3728328
Anti-phospho-TAK1 (Ser412) - 3772442	3772442
Anti-phospho-TAK1 (Ser412) - 4041255	4041255
Anti-phospho-TAK1 (Ser412) - 4179417	4179417
Anti-phospho-TAK1 (Ser412) - NRG1881309	NRG1881309
Anti-phospho-TAK1 (Ser412) -2611049	2611049
Anti-phospho-TAK1 (Ser412) -2638121	2638121

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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