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196805 Sigma-AldrichBax Channel Blocker - CAS 335165-69-0 - Calbiochem

A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1

Primary Target: Bax-channel forming activity

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
335165-69-0	C₁₉H₂₁Br₂N₃O

价格及供货情况

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Description
Overview	A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC₅₀ = 520 nM in a liposome channel assay).
Catalogue Number	196805
Brand Family	Calbiochem®
Synonyms	(±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1

References
References	Peixoto, P., et al. 2009. Biochem J. 423, 381. Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.

Product Information
CAS number	335165-69-0
ATP Competitive	N
Form	Off-white solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₁₉H₂₁Br₂N₃O
Chemical formula	C₁₉H₂₁Br₂N₃O
HS Code	2933 59 19
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	Bax-channel forming activity
Primary Target IC<sub>50</sub>	520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
196805-5MGCN	04055977206524

Documentation

Bax Channel Blocker - CAS 335165-69-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Bax Channel Blocker - CAS 335165-69-0 - Calbiochem 分析证书

标题	批号
196805	输入批号

参考

参考信息概述
Peixoto, P., et al. 2009. Biochem J. 423, 381. Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-July-2018 JSW
Synonyms	(±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1
Description	A cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel activity.
Form	Off-white solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	335165-69-0
Chemical formula	C₁₉H₂₁Br₂N₃O
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Peixoto, P., et al. 2009. Biochem J. 423, 381. Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Other Apoptosis Inhibitors

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