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208920 Calmodulin Kinase IINtide - Calbiochem

A potent and specific inhibitor of CaMK II (IC₅₀ = 50 nM for both the total and Ca2+-independent CaMK II activity).

Calmodulin Kinase IINtide - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: KRPPKLGQIGRAKRVVIEDDRIDDVLK-OH

Primary Target: Cam Kinase-2
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208920
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概述

Replacement Information

重要规格表

Empirical Formula
C₁₃₆H₂₄₀N₄₄O₃₉

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
208920-1MGCN
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      		 塑胶安瓿;塑胶针药瓶 1 mg
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      Description
      OverviewA potent and specific inhibitor of CaMK II (IC50 = 50 nM for both the total and Ca2+-independent CaMK II activity). Exhibits inhibitory activity across converged species, including rat brain, goldfish brain, and Drosophila (IC50 range 100-400 nM). Does not affect the activities of CaMK I, CaMK IV, CaMKK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of CaMK IIN.
      Catalogue Number208920
      Brand Family Calbiochem®
      SynonymsKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
      References
      ReferencesSoderling, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
      Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
      Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
      Product Information
      ATP CompetitiveN
      FormOff-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₃₆H₂₄₀N₄₄O₃₉
      Chemical formulaC₁₃₆H₂₄₀N₄₄O₃₉
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCam Kinase-2
      Primary Target IC<sub>50</sub>50 nM for both the total and Ca2+-independent CaMK II activity
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      208920-1MGCN 04055977219548

      Documentation

      Calmodulin Kinase IINtide - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Calmodulin Kinase IINtide - Calbiochem 分析证书

      标题批号
      208920

      参考

      参考信息概述
      Soderling, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
      Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
      Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
      DescriptionA potent and specific inhibitor of calmodulin kinase II (CaM-KII) (IC50 = 50 nM for both total and Ca2+-independent activities of CaM-KII). Does not affect the activities of CaM-KI, CaM-KIV, CaM-KK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of the inhibitory protein, CaM-KIIN. A cell-permeable version is available under Cat. No. 208921.
      FormOff-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃₆H₂₄₀N₄₄O₃₉
      Peptide SequenceH-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesSoderling, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
      Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
      Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.