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An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Carbachol is totally resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.
Catalogue Number
212385
Brand Family
Calbiochem®
Synonyms
Carbamoylcholine Chloride
References
References
Jence, M., et al. 1995. J. Neurochem. 64, 1605. Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248. Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847. Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82. Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.
Agonist for nicotinic and muscarinic acetylcholine receptors
Purity
≥98% by titration
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
GA0875000
Safety Information
R Phrase
R: 26/27/28-36/37/38
Very toxic by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin.
S Phrase
S: 22-36/37/39-45
Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Highly Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+15°C to +30°C
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Jence, M., et al. 1995. J. Neurochem. 64, 1605. Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248. Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847. Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82. Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
23-February-2023 JSW
Synonyms
Carbamoylcholine Chloride
Description
An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca2+ and InsP3 and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.
Form
White fine crystalline solid
CAS number
51-83-2
RTECS
GA0875000
Chemical formula
C₆H₁₅ClN₂O₂
Structure formula
Purity
≥98% by titration
Solubility
H₂O (100 mg/ml), Ethanol (20 mg/ml), and Methanol(100 mg/ml)
Storage
+15°C to +30°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity
Highly Toxic
Merck USA index
14, 1779
References
Jence, M., et al. 1995. J. Neurochem. 64, 1605. Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248. Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847. Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82. Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.
