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218697 Sigma-AldrichCasein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem

Casein Kinase II Inhibitor I, CAS 17374-26-4, is a cell-permeable, selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (IC50 = 900 nM for rat liver CK2).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: TBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor

Primary Target: CK2 rat liver, human recombinant

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
17374-26-4	C₆HBr₄N₃

价格及供货情况

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Description
Overview	A cell-permeable benzotriazolo compound that acts as a higly selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC₅₀ = 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively) and DYRK (IC₅₀ < 1 µM for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC₅₀ = 20 and 60 µM, using DNA and RNA substrate, respectively) and WNV (IC₅₀ = 1.7 and 900 nM, using DNA and RNA substrate, respectively). A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218708) in DMSO, is also available.
Catalogue Number	218697
Brand Family	Calbiochem®
Synonyms	TBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor

References
References	Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645. Sarno, S., et al. 2003. Biochem. J. 374, 639. Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129. Ruzzene, M., et al. 2002. Biochem. J. 364, 41. Sarno, S., et al. 2001. FEBS Lett. 496, 44. Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.

Product Information
CAS number	17374-26-4
ATP Competitive	Y
Form	White solid
Hill Formula	C₆HBr₄N₃
Chemical formula	C₆HBr₄N₃
HS Code	2933 99 99
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	Casein Kinase II Inhibitor I, CAS 17374-26-4, is a cell-permeable, selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (IC50 = 900 nM for rat liver CK2).

Biological Information
Primary Target	CK2 rat liver, human recombinant
Primary Target IC<sub>50</sub>	900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively; < 1 µM for DYRK1a
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
218697-10MGCN	04055977202502

Documentation

Casein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Casein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem 分析证书

标题	批号
218697	输入批号

参考

参考信息概述
Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645. Sarno, S., et al. 2003. Biochem. J. 374, 639. Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129. Ruzzene, M., et al. 2002. Biochem. J. 364, 41. Sarno, S., et al. 2001. FEBS Lett. 496, 44. Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-January-2009 JSW
Synonyms	TBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor
Description	A cell-permeable benzotriazolo compound that acts as a highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC₅₀ <1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC₅₀ = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC₅₀ = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	17374-26-4
Chemical formula	C₆HBr₄N₃
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645. Sarno, S., et al. 2003. Biochem. J. 374, 639. Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129. Ruzzene, M., et al. 2002. Biochem. J. 364, 41. Sarno, S., et al. 2001. FEBS Lett. 496, 44. Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Casein Kinase (CK) Inhibitors

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