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217694 Sigma-AldrichCdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem

The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
93718-83-3	C₁₄H₁₄O₄S₂

价格及供货情况

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Description
Overview	A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (K_i = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G₂M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC₅₀ = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
Catalogue Number	217694
Brand Family	Calbiochem®
Synonyms	(2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX

References
References	Dulyaninova, N.G., et al. 2011. Biochemistry 50, 7218. Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.

Product Information
CAS number	93718-83-3
Form	Orange solid
Hill Formula	C₁₄H₁₄O₄S₂
Chemical formula	C₁₄H₁₄O₄S₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
217694-10MGCN	04055977202304

Documentation

Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem 分析证书

标题	批号
217694	输入批号

参考

参考信息概述
Dulyaninova, N.G., et al. 2011. Biochemistry 50, 7218. Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-June-2012 JSW
Synonyms	(2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
Description	A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (K_i = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G₂M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC₅₀ = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
Form	Orange solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	93718-83-3
Chemical formula	C₁₄H₁₄O₄S₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (100 mg/ml; clear red solution)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Dulyaninova, N.G., et al. 2011. Biochemistry 50, 7218. Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors

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