Millipore Sigma Vibrant Logo

204897 Complement C4b, Human

Complement C4b, Human, is a native, 193 kDa glycoprotein composed of the modified C4 α-chain (α') and intact β- and γ-chains complement component.

Complement C4b, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
View Products on Sigmaaldrich.com
204897
查看价格及供货情况

概述

Replacement Information

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
204897-250UGCN
正在查询供货情况......
—
目前缺货 目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余：另行通知
      其余：另行通知
      另行通知
      联系客户服务
      Contact Customer Service

      		 塑胶安瓿;塑胶针药瓶 250 μg
      正在检索价格......
      无法检索价格。
      最小订购数量为倍数
      Maximum Quantity is
      以订单确认为准 更多信息
      您节约了 ()。
       
      —
      Request Pricing
      		 —
      Description
      OverviewNative, human C4b complement component. Cleavage of the C4 α-chain at peptide bond 77 by activated C1 enzyme results in the production of C4a (M.W. 8,758) and C4b (M.W. 193,000) fragments. The C4b fragment is a glycoprotein composed of the modified C4 α-chain (α′) and intact β- and γ-chains. Like C3b, C4b has the transient ability to form a covalent ester bond with a variety of target cell surfaces. Once bound to the target surface, C4b becomes an essential non-enzymatic subunit of the classical pathway C3 cleaving enzyme (C4b,C2a). In addition, surface bound C4b has opsonic and immune adherence activities which are mediated via binding to the CR1 (CD35) complement receptor which is found on a variety of inflammatory cells.
      Catalogue Number204897
      Brand Family Calbiochem®
      References
      ReferencesWeisman, H.F., et al. 1990. Science 249, 146.
      Holers, M.V., et al. 1985. Immunology Today 6, 188.
      Product Information
      FormLiquid
      FormulationIn PBS, pH 7.2.
      HS Code3002 12 19
      PreservativeNone
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from plasma of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsIgG, IgA, IgM, Factor B, Factor H, C3, ceruloplasmin, or albumin: ≤trace amounts
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      204897-250UGCN 04055977219852

      Documentation

      Complement C4b, Human MSDS

      职位

      物料安全数据表 (MSDS) 

      Complement C4b, Human 分析证书

      标题批号
      204897

      参考

      参考信息概述
      Weisman, H.F., et al. 1990. Science 249, 146.
      Holers, M.V., et al. 1985. Immunology Today 6, 188.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-May-2008 RFH
      DescriptionNative, human C4b complement component. Cleavage of the C4 α-chain at peptide bond 77 by activated C1 enzyme results in the production of C4a (M.W. 8,758) and C4b (M.W. 193,000) fragments. The C4b fragment is a glycoprotein composed of the modified C4 α-chain (α') and intact β- and γ-chains. Like C3b, C4b has the transient ability to form a covalent ester bond with a variety of target cell surfaces. Once bound to the target surface, C4b becomes an essential non-enzymatic subunit of the classical pathway C3 cleaving enzyme (C4b,C2a). In addition, surface bound C4b has opsonic and immune adherence activities, which are mediated via binding to the CR1 (CD35) complement receptor, which is found on a variety of inflammatory cells.
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from plasma of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥95% by SDS-PAGE
      ContaminantsIgG, IgA, IgM, Factor B, Factor H, C3, ceruloplasmin, or albumin: ≤trace amounts
      PreservativeNone
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesWeisman, H.F., et al. 1990. Science 249, 146.
      Holers, M.V., et al. 1985. Immunology Today 6, 188.