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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

204863 Sigma-AldrichComplement iC3b, Human

Complement iC3b, Human, is a native form that is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein.

Complement iC3b, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

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概述

Replacement Information

价格及供货情况

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Description
Overview	Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43 kDa and M.W. 63 kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75 kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
Catalogue Number	204863
Brand Family	Calbiochem®

References
References	Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99. Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.

Product Information
Form	Liquid
Formulation	In PBS, pH 7.2.
Preservative	None
Quality Level	MQ100

Applications

Biological Information
Purity	≥90% by SDS-PAGE
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Contaminants	IgG, IgA, IgM, C5, Factor H, or Factor I: ≤trace amounts

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
204863-250UGCN	04055977219647

Documentation

Complement iC3b, Human MSDS

职位
物料安全数据表 (MSDS)

Complement iC3b, Human 分析证书

标题	批号
204863	输入批号

参考

参考信息概述
Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99. Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-May-2008 RFH
Description	Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α' polypeptides of M.W. 43,000 and M.W. 63,000 are disulfide bonded to the intact C3 b-chain (M.W. 75,000). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
Form	Liquid
Formulation	In PBS, pH 7.2.
Concentration Label	Please refer to vial label for lot-specific concentration
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity	≥90% by SDS-PAGE
Contaminants	IgG, IgA, IgM, C5, Factor H, or Factor I: ≤trace amounts
Preservative	None
Storage	Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).
Toxicity	Standard Handling
References	Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99. Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.

种类

Life Science Research > Proteins and Enzymes > Other Proteins

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