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400093 Sigma-AldrichHIF-PHD Inhibitor II, JNJ-42041935 - CAS 1193383-09-3 - Calbiochem

The HIF-PHD Inhibitor II, JNJ-42041935 controls the biological activity of HIF-PHD. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid, HIF Prolyl Hydroxylase Inhibitor II

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1193383-09-3	C₁₂H₆ClF₃N₄O₃

价格及供货情况

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Description
Overview	A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pK_i = 7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC₅₀ ~ 4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1α levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100 µM/kg). Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration.
Catalogue Number	400093
Brand Family	Calbiochem®
Synonyms	1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid, HIF Prolyl Hydroxylase Inhibitor II

References
References	Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press. Barrett, T.D., et al. 2011. Mol. Pharmacol. 79, 910. Rosen, M.D., et al. 2010. ACS Med. Chem. Lett. 1, 526.

Product Information
CAS number	1193383-09-3
Form	White solid
Hill Formula	C₁₂H₆ClF₃N₄O₃
Chemical formula	C₁₂H₆ClF₃N₄O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
400093-10MGCN	04055977212402

Documentation

HIF-PHD Inhibitor II, JNJ-42041935 - CAS 1193383-09-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

HIF-PHD Inhibitor II, JNJ-42041935 - CAS 1193383-09-3 - Calbiochem 分析证书

标题	批号
400093	输入批号

参考

参考信息概述
Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press. Barrett, T.D., et al. 2011. Mol. Pharmacol. 79, 910. Rosen, M.D., et al. 2010. ACS Med. Chem. Lett. 1, 526.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-August-2012 JSW
Synonyms	1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid, HIF Prolyl Hydroxylase Inhibitor II
Description	A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pK_i = 7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC₅₀ ~ 4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1α levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100 µM/kg).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1193383-09-3
Chemical formula	C₁₂H₆ClF₃N₄O₃
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press. Barrett, T.D., et al. 2011. Mol. Pharmacol. 79, 910. Rosen, M.D., et al. 2010. ACS Med. Chem. Lett. 1, 526.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Angiogenesis Inhibitors > Angiogenesis Inhibitors

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