数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

385570 Sigma-AldrichHeat Shock Factor 1 Inhibitor, KRIBB11 - CAS 342639-96-7 - Calbiochem

The Heat Shock Factor 1 Inhibitor, KRIBB11 controls the biological activity of Heat Shock Factor 1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N²-(1H-Indazol-5-yl)-N⁶-methyl-3-nitropyridine-2,6-diamine , HSF1 Inhibitor, KRIBB11, Hsp70 Induction Inhibitor II, Heat Shock Protein Inhibitor III, p-TEFb hsp70 Promoter Recruitment Inhibitor

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
342639-96-7	C₁₃H₁₂N₆O₂

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
385570-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable 2,6-diaminopyridine compound that interacts with HSF1 in a reversible manner and prevents HSF1 from recruiting p-TEFb to the hsp70 promoter site (IC₅₀ ≤3 µM in HCT-116 ChIP assays), a critical step for heat shock-induced transcription activation (IC₅₀ <1, <3, <5, and <10 µM, respectively, against reporter, HSP47, HSP27, and HSP70 transcription in HCT-116 cultures). Reported to exhibit antiproliferation activity against several cancer cultures in vitro (IC₅₀ from 3 to 8 µM) and effectively suppress HCT-116-derived tumor growth in mice in vivo (50 mg/kg i.p.).
Catalogue Number	385570
Brand Family	Calbiochem®
Synonyms	N²-(1H-Indazol-5-yl)-N⁶-methyl-3-nitropyridine-2,6-diamine , HSF1 Inhibitor, KRIBB11, Hsp70 Induction Inhibitor II, Heat Shock Protein Inhibitor III, p-TEFb hsp70 Promoter Recruitment Inhibitor

References
References	Yoon, Y.J., et al. 2010. J. Biol. Chem. 286, 1737.

Product Information
CAS number	342639-96-7
Form	Orange-yellow solid
Hill Formula	C₁₃H₁₂N₆O₂
Chemical formula	C₁₃H₁₂N₆O₂
Structure formula Image
Quality Level	MQ200

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
385570-10MGCN	04055977190274

Documentation

Heat Shock Factor 1 Inhibitor, KRIBB11 - CAS 342639-96-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Heat Shock Factor 1 Inhibitor, KRIBB11 - CAS 342639-96-7 - Calbiochem 分析证书

标题	批号
385570	输入批号

参考

参考信息概述
Yoon, Y.J., et al. 2010. J. Biol. Chem. 286, 1737.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-April-2012 JSW
Synonyms	N²-(1H-Indazol-5-yl)-N⁶-methyl-3-nitropyridine-2,6-diamine , HSF1 Inhibitor, KRIBB11, Hsp70 Induction Inhibitor II, Heat Shock Protein Inhibitor III, p-TEFb hsp70 Promoter Recruitment Inhibitor
Description	A cell-permeable 2,6-diaminopyridine compound that interacts with HSF1 (heat shock factor 1) in a reversible manner and prevents HSF1 from recruiting p-TEFb (positive transcription elongation factor b) to the hsp70 promoter site (IC₅₀ ≤3 µM in HCT-116 ChIP assays), a critical step for the p-TEFb CDK9 subunit-catalyzed pol II CTD (RNA polymerase II c-terminal domain) Ser-2 phosphorylation and transcription activation upon heat shock induction (IC₅₀ <1, <3, <5, and <10 µM, respectively, against reporter, HSP47, HSP27, and HSP70 transcription in HCT-116 cultures). Reported to exhibit antiproliferation activity against several cancer cultures in vitro (IC₅₀ ranges from 3 to 8 µM) and effectively suppress HCT-116-derived tumor growth in mice in vivo (by 47.4% on day 31; single i.p. dosage of 50 mg/kg on day 13 after cancer implantation). Does not affect TNF-α-induced NF-κB activity in HeLa or heat shock-induced HSF1 ser230 phosphorylation and promoter association in HCT-116 even at concentrations as high as 10 µM.
Form	Orange-yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	342639-96-7
Chemical formula	C₁₃H₁₂N₆O₂
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (50 mg/ml; brown solution)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Yoon, Y.J., et al. 2010. J. Biol. Chem. 286, 1737.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

此产品已添加到您的购物车。