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373400 Sigma-AldrichHh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem

The Hh/Gli Antagonist, GANT58, also referenced under CAS 64048-12-0, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
64048-12-0	C₂₄H₁₆N₄S

Description
Overview	A cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
Catalogue Number	373400
Brand Family	Calbiochem®
Synonyms	4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503

References
References	Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.

Product Information
CAS number	64048-12-0
Form	Yellow solid
Hill Formula	C₂₄H₁₆N₄S
Chemical formula	C₂₄H₁₆N₄S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Regulatory Review
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
373400	0

Documentation

Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem 分析证书

标题	批号
373400	输入批号

参考

参考信息概述
Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-April-2011 RFH
Synonyms	4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503
Description	A cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC₅₀ ~5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	64048-12-0
Chemical formula	C₂₄H₁₆N₄S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Regulatory Review
References	Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology > Sonic Hedgehog Signaling Inhibitors

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