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382110 Sigma-AldrichHistone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem

The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
932749-62-7	C₂₀H₁₆Br₂O₃

价格及供货情况

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Description
Overview	A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC₅₀ = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC₅₀ ≤ 40 µM) and induce chromatin condensation in HeLa cells.
Catalogue Number	382110
Brand Family	Calbiochem®
Synonyms	2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I

References
References	Costi, R., et al. 2007. J. Med. Chem. 50, 1973.

Product Information
CAS number	932749-62-7
Form	Yellow solid
Hill Formula	C₂₀H₁₆Br₂O₃
Chemical formula	C₂₀H₁₆Br₂O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
382110-10MGCN	04055977213096

Documentation

Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem 分析证书

标题	批号
382110	输入批号

参考

参考信息概述
Costi, R., et al. 2007. J. Med. Chem. 50, 1973.

小册子

标题
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-April-2011 RFH
Synonyms	2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I
Description	A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC₅₀ = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC₅₀ ≤40 µM) and induce chromatin condensation in HeLa cells.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	932749-62-7
Chemical formula	C₂₀H₁₆Br₂O₃
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (25 mg/ml) or Ethanol (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.
Toxicity	Standard Handling
References	Costi, R., et al. 2007. J. Med. Chem. 50, 1973.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors

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