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382172 Sigma-AldrichHistone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem

The Histone Deacetylase Inhibitor VI, HNHA, also referenced under CAS 926908-04-5, controls the biological activity of Histone Deacetylase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
技术信息
Data Sheet

同义词: N-Hydroxy-7-(2-naphthylthio)heptanomide

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
926908-04-5	C₁₇H₂₁NO₂S

价格及供货情况

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Description
Overview	A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC₅₀ = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
Catalogue Number	382172
Brand Family	Calbiochem®
Synonyms	N-Hydroxy-7-(2-naphthylthio)heptanomide

References
References	Kim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.

Product Information
CAS number	926908-04-5
Form	White solid
Hill Formula	C₁₇H₂₁NO₂S
Chemical formula	C₁₇H₂₁NO₂S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 22-24/25-36/37/39 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
382172-10MGCN	04055977212785

Documentation

Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem 分析证书

标题	批号
382172	输入批号

参考

参考信息概述
Kim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.

技术信息

标题
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-April-2011 RFH
Synonyms	N-Hydroxy-7-(2-naphthylthio)heptanomide
Description	A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC₅₀ = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	926908-04-5
Chemical formula	C₁₇H₂₁NO₂S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (100 mg/ml) or Methanol (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Kim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors

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