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401477 IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem

The IκB Kinase Inhibitor Peptide, Cell-Permeable controls the biological activity of IκB Kinase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂

Primary Target: LPS-induced IκB degradation by IKK in RAW 264.7 cells
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401477
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概述

Replacement Information

重要规格表

Empirical Formula
C₁₃₈H₂₂₉N₃₇O₄₅S

价格及供货情况

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401477-1MGCN
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      		 塑胶安瓿;塑胶针药瓶 1 mg
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      Description
      OverviewA 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (< 50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.
      Catalogue Number401477
      Brand Family Calbiochem®
      SynonymsAc-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂
      References
      ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
      Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₃₈H₂₂₉N₃₇O₄₅S
      Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₅S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLPS-induced IκB degradation by IKK in RAW 264.7 cells
      Primary Target IC<sub>50</sub><50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      401477-1MGCN 04055977211924

      Documentation

      IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem 分析证书

      标题批号
      401477

      参考

      参考信息概述
      Swaroop, N., et al. 2001. Pharm. Res. 18, 1631.
      Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2007 RFH
      SynonymsAc-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂
      DescriptionA 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence, linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IkB kinases (IKK) in RAW 264.7 cells (<50 μg/ml) and prevents NF-κB activation.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₅S
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂
      Purity≥95% by HPLC
      SolubilityPBS, pH 7.4 (1 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
      Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.