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401487 Sigma-AldrichIKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem

The IKK-2 Inhibitor VIII, also referenced under CAS 406208-42-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrile, ACHP

Primary Target: IKK-2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
406208-42-2	C₂₁H₂₄N₄O₂

价格及供货情况

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Description
Overview	A cell-permeable piperidinyl-pyridine compound that acts as a selective inhibitor of IKK-2 activity (IC₅₀ = 8.5 and 250 nM for IKK-2 and IKK-1, respectively) with little effect towards IKK-3, Syk, and MKK4 (IC₅₀ >20 µM). Exhibits good aqueous solubility (0.12 mg/ml in pH 7.4 isotonic buffer) and potent activity in various cellular assays in vitro (IC₅₀ <150 nM). Shown to be orally bioavailable both in rats and mice (BA = 60% and 16%, respectively) and effectively inhibit arachidonic acid-induced swelling in a murine ear edema model in vivo.
Catalogue Number	401487
Brand Family	Calbiochem®
Synonyms	2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrile, ACHP

References
References	Murata, T., et al. 2004. Bioorg. Med. Chem. Lett. 14, 4019.

Product Information
CAS number	406208-42-2
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₂₁H₂₄N₄O₂
Chemical formula	C₂₁H₂₄N₄O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	IKK-2
Primary Target IC<sub>50</sub>	8.5 and 250 nM for IKK-2 and IKK-1, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
401487-1MGCN	04055977212044

Documentation

IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem 分析证书

标题	批号
401487	输入批号

参考

参考信息概述
Murata, T., et al. 2004. Bioorg. Med. Chem. Lett. 14, 4019.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-April-2011 RFH
Synonyms	2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrile, ACHP
Description	A cell-permeable piperidinyl-pyridine compound that acts as a selective inhibitor of IKK-2 activity (IC₅₀ = 8.5 and 250 nM for IKK-2 and IKK-1, respectively) with little effect towards IKK-3, Syk, and MKK4 (IC₅₀ >20 µM). Exhibits good aqueous solubility (0.12 mg/ml in pH 7.4 isotonic buffer) and potent activity in various cellular assays in vitro (IC₅₀ <150 nM). Shown to be orally bioavailable both in rats and mice (BA = 60% and 16%, respectively) and effectively inhibit arachidonic acid-induced swelling in a murine ear edema model in vivo.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	406208-42-2
Chemical formula	C₂₁H₂₄N₄O₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml). Sonication is required for complete solubilization.
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Murata, T., et al. 2004. Bioorg. Med. Chem. Lett. 14, 4019.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

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