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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

401485 Sigma-AldrichInSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem

The InSolution™ IKK-2 Inhibitor, SC-514 controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: IKK-2

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₉H₈N₂OS₂

价格及供货情况

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Description
Catalogue Number	401485
Brand Family	Calbiochem®

References
References	Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817. Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.

Product Information
ATP Competitive	Y
Form	Clear to pale yellow Liquid
Formulation	A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
Hill Formula	C₉H₈N₂OS₂
Chemical formula	C₉H₈N₂OS₂
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	IKK-2
Primary Target IC<sub>50</sub>	~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
401485-1MGCN	04055977212006

Documentation

InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem 分析证书

标题	批号
401485	输入批号

参考

参考信息概述
Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817. Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-July-2008 RFH
Description	A cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC₅₀ ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC₅₀ >200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
Form	Clear to pale yellow Liquid
Formulation	A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₉H₈N₂OS₂
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).
Toxicity	Irritant
References	Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817. Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

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