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475913 Mycophenolic Acid - CAS 24280-93-1 - Calbiochem

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA

Primary Target: Inosine monophosphate dehydrogenase
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      概述

      Replacement Information

      重要规格表

      CAS #Empirical Formula
      24280-93-1C₁₇H₂₀O₆
      Description
      OverviewAn immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
      Catalogue Number475913
      Brand Family Calbiochem®
      Synonyms6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA
      References
      ReferencesLangman, L.J., et al. 1995. Clin. Chem. 41, 295.
      Senda, M., et al. 1995. Transplantation 60, 1143.
      Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
      Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
      Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
      Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.
      Product Information
      CAS number24280-93-1
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₁₇H₂₀O₆
      Chemical formulaC₁₇H₂₀O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInosine monophosphate dehydrogenase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSMP8050000
      Safety Information
      R PhraseR: 20/21/22-40

      Harmful by inhalation, in contact with skin and if swallowed.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      475913 0

      Documentation

      Mycophenolic Acid - CAS 24280-93-1 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Mycophenolic Acid - CAS 24280-93-1 - Calbiochem 分析证书

      标题批号
      475913

      参考

      参考信息概述
      Langman, L.J., et al. 1995. Clin. Chem. 41, 295.
      Senda, M., et al. 1995. Transplantation 60, 1143.
      Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
      Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
      Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
      Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-May-2008 RFH
      Synonyms6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA
      DescriptionAn immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of IMP dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
      FormWhite to off-white solid
      CAS number24280-93-1
      RTECSMP8050000
      Chemical formulaC₁₇H₂₀O₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityEthanol or 100 mM NaOH (10 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14 6327
      ReferencesLangman, L.J., et al. 1995. Clin. Chem. 41, 295.
      Senda, M., et al. 1995. Transplantation 60, 1143.
      Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
      Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
      Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
      Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.