495620 Sigma-AldrichOlomoucine - CAS 101622-51-9 - Calbiochem
A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.
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同义词: Olomoucine
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 101622-51-9 | C₁₅H₁₈N₆O |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
|---|---|---|---|---|---|---|
| 495620-1MGCN |
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塑胶安瓿;塑胶针药瓶 | 1 mg |
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| 495620-5MGCN |
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塑胶安瓿;塑胶针药瓶 | 5 mg |
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| Description | |
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| Overview | A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B (IC50 = 7 µM) and related kinases including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44 MAP kinase (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D (IC50 > 1 mM), and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases at 1 mM. Known to inhibit DNA synthesis in interleukin-2-stimulated T lymphocytes and trigger G1 arrest similar to that observed in interleukin-2-deprived cells. Also used to synchronize cells in G1. A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495624) in DMSOis also available. |
| Catalogue Number | 495620 |
| Brand Family | Calbiochem® |
| Synonyms | Olomoucine |
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| CAS number | 101622-51-9 |
| ATP Competitive | Y |
| Form | Crystalline solid |
| Hill Formula | C₁₅H₁₈N₆O |
| Chemical formula | C₁₅H₁₈N₆O |
| HS Code | 2933 59 99 |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 495620-1MGCN | 04055977199789 |
| 495620-5MGCN | 04055977199796 |
Documentation
Olomoucine - CAS 101622-51-9 - Calbiochem MSDS
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Olomoucine - CAS 101622-51-9 - Calbiochem 分析证书
| 标题 | 批号 |
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| 495620 |
参考
| 参考信息概述 |
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| Abraham, R.T., et al. 1995. Biol. Cell 83, 105. Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715. Glab, N., et al. 1994. FEBS Lett. 353, 207. Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771. |