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The PARP Inhibitor IX, EB-47 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>>The PARP Inhibitor IX, EB-47 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<
PARP Inhibitor IX, EB-47 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of PARP-1 (IC50 = 45 nM). Shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
Catalogue Number
324473
Brand Family
Calbiochem®
References
References
Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett.14, 81.
Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett.14, 81.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
19-June-2008 RFH
Description
A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) (IC50 = 45 nM). Reported to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₂₄H₂₇N₉O₆·2HCl·2H₂O
Structure formula
Purity
≥95% by HPLC
Solubility
H₂O (50 mg/ml)
Storage
Protect from light
-20°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Carcinogenic / Teratogenic
References
Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett.14, 81.
