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528112 PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem

The PI 3-Kγ/CKII Inhibitor, also referenced under CAS 1138220-19-5, controls the biological activity of PI 3-Kγ/CKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: (5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, PI 3-K Inhibitor XII, AS-252424

Primary Target: PI 3-Kγ/CKII
528112
  
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      概述

      Replacement Information

      重要规格表

      CAS #Empirical Formula
      1138220-19-5C₁₄H₈FNO₄S
      Description
      OverviewA cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC50 >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
      Catalogue Number528112
      Brand Family Calbiochem®
      Synonyms(5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, PI 3-K Inhibitor XII, AS-252424
      References
      ReferencesPomel, V., et al. 2006. J. Med. Chem. 49, 3857.
      Product Information
      CAS number1138220-19-5
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₄H₈FNO₄S
      Chemical formulaC₁₄H₈FNO₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPI 3-Kγ/CKII
      Primary Target IC<sub>50</sub>20 nM against PI 3-Kγ and CKII
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      528112 0

      Documentation

      PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem 分析证书

      标题批号
      528112

      参考

      参考信息概述
      Pomel, V., et al. 2006. J. Med. Chem. 49, 3857.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonyms(5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, PI 3-K Inhibitor XII, AS-252424
      DescriptionA cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC50 >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1138220-19-5
      Chemical formulaC₁₄H₈FNO₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPomel, V., et al. 2006. J. Med. Chem. 49, 3857.