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528118 Sigma-AldrichPI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem

PI 3-Kδ Inhibitor X, IC87114, CAS 371242-69-2, is a cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110, p110, and p110, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Phosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
371242-69-2	C₂₂H₁₉N₇O

价格及供货情况

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Description
Overview	A cell permeable, selective inhibitor of PI 3-Kδ (IC₅₀= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
Catalogue Number	528118
Brand Family	Calbiochem®
Synonyms	Phosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X

References
References	Billottet, C., et al. 2009. Cancer Res. 69,1027. Ali, K., et al. 2008. J. Immunol. 180, 2538.

Product Information
CAS number	371242-69-2
Form	White powder
Hill Formula	C₂₂H₁₉N₇O
Chemical formula	C₂₂H₁₉N₇O
Structure formula Image
Quality Level	MQ100

Applications
Application	PI 3-Kδ Inhibitor X, IC87114, CAS 371242-69-2, is a cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110, p110, and p110, respectively).

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
528118-5MGCN	04055977197013

Documentation

PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem 分析证书

标题	批号
528118	输入批号

参考

参考信息概述
Billottet, C., et al. 2009. Cancer Res. 69,1027. Ali, K., et al. 2008. J. Immunol. 180, 2538.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	01-September-2010 RFH
Synonyms	Phosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X
Description	A cell permeable, selective inhibitor of PI 3-Kδ (IC₅₀= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
Form	White powder
CAS number	371242-69-2
Chemical formula	C₂₂H₁₉N₇O
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Billottet, C., et al. 2009. Cancer Res. 69,1027. Ali, K., et al. 2008. J. Immunol. 180, 2538.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Phosphatidylinositol 3-Kinase (PI 3-kinase) Inhibitors

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