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The PME-1 Inhibitor, AMZ-30 controls the biological activity of PME-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>>The PME-1 Inhibitor, AMZ-30 controls the biological activity of PME-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<
PME-1 Inhibitor, AMZ-30 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable sulfonyl acrylonitrile compound that acts as a potent
and irreversible inhibitor of protein phosphatase methylesterase-1
(PME-1; IC50 = 600 nM and 2.5 µM in human cell lysates and in HEK 293T cells, respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20 µM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable sulfonyl acrylonitrile compound that acts as a potent and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 600 nM and 2.5 µM in human cell lysates and in HEK 293T cells, (respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20 µM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells.
Form
Yellow solid
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₉H₁₃FN₃O₆S₂
Structure formula
Purity
≥97% by HPLC
Solubility
DMSO (50 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
