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528208 Sigma-AldrichPlasminogen Activator Inhibitor-1, Mutant, Human, Recombinant - Calbiochem

The Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant controls the biological activity of Plasminogen Activator. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: PAI-1, Mutant

Primary Target: Plasminogen Activator

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概述

Replacement Information

价格及供货情况

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Description
Overview	Highly purified preparation of an altered form of human PAI-1 containing four mutated amino acids. Mutant PAI-1 is virtually unable to go latent and is stable at elevated temperature and pH for extended periods of time (t_½ = 145 hours at 37°C, pH 7.4). Inhibits uPA (K_i = 5.1 x 10⁶ M^-1 sec^-1) and tPA (K_i = 7.9 x 10⁵ M^-1 sec^-1).
Catalogue Number	528208
Brand Family	Calbiochem®
Synonyms	PAI-1, Mutant

References
References	Berkenpas, M.B., et al. 1995. EMBO J. 14, 2969.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	In 100 mM NaCl, 50 mM sodium phosphate buffer, 1 mM EDTA, pH 6.6.
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	Plasminogen Activator
Primary Target K<sub>i</sub>	5.1 x 106 M-1 sec-1, 7.9 x 105 M-1 sec-1 against uPA and tPA, respectively
Purity	≥95% by SDS-PAGE assay
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
528208-50UGCN	04055977196498

Documentation

Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant - Calbiochem 分析证书

标题	批号
528208	输入批号

参考

参考信息概述
Berkenpas, M.B., et al. 1995. EMBO J. 14, 2969.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	22-July-2024 JSW
Synonyms	PAI-1, Mutant
Description	Highly purified preparation of an altered form of human PAI-1 containing four mutated amino acids. Mutant PAI-1 is virtually unable to go latent and is stable at elevated temperature and pH for extended periods of time (t_½ = 145 h at 37°C, pH 7.4). Inhibits uPA (K_i = 5.1 x 10⁶ M^-1sec^-1) and tPA (K_i = 7.9 x 10⁵ M^-1sec^-1).
Form	Liquid
Formulation	In 100 mM NaCl, 50 mM sodium phosphate buffer, 1 mM EDTA, pH 6.6.
Concentration Label	Please refer to vial label for lot-specific concentration
Purity	≥95% by SDS-PAGE assay
Storage	Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).
Toxicity	Standard Handling
References	Berkenpas, M.B., et al. 1995. EMBO J. 14, 2969.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Plasminogen Activator Inhibitors

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