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528283 Sigma-AldrichPolo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem

The Polo-like Kinase Inhibitor II, BTO-1, also referenced under CAS 40647-02-7, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 5-Cyano-7-nitro-2-(benzothiazolo-N-oxide)-carboxamide

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
40647-02-7	C₉H₄N₄O₄S

价格及供货情况

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Description
Overview	A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC₅₀ = 8.0 µM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 µM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.
Catalogue Number	528283
Brand Family	Calbiochem®
Synonyms	5-Cyano-7-nitro-2-(benzothiazolo-N-oxide)-carboxamide

References
References	Brennan, I.M., et al. 2007. PloS ONE 2, e409. Peters, U., et al. 2006. Nat. Chem. Biol. 2, 618. McInnes, C., et al. 2006. Nat. Chem. Biol. 2, 608.

Product Information
CAS number	40647-02-7
Form	Beige to brown solid
Hill Formula	C₉H₄N₄O₄S
Chemical formula	C₉H₄N₄O₄S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 20/21/22-36/37/38 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36/37 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
528283-2MGCN	04055977196580

Documentation

Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem 分析证书

标题	批号
528283	输入批号

参考

参考信息概述
Brennan, I.M., et al. 2007. PloS ONE 2, e409. Peters, U., et al. 2006. Nat. Chem. Biol. 2, 618. McInnes, C., et al. 2006. Nat. Chem. Biol. 2, 608.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-August-2016 JSW
Synonyms	5-Cyano-7-nitro-2-(benzothiazolo-N-oxide)-carboxamide
Description	A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC₅₀ = 8.0 µM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 µM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.
Form	Beige to brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	40647-02-7
Chemical formula	C₉H₄N₄O₄S
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (1 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Harmful
References	Brennan, I.M., et al. 2007. PloS ONE 2, e409. Peters, U., et al. 2006. Nat. Chem. Biol. 2, 618. McInnes, C., et al. 2006. Nat. Chem. Biol. 2, 608.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Polo-like Kinase Inhibitors

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