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A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.
Catalogue Number
552233
Brand Family
Calbiochem®
References
References
Mooney, R. 1992. J. Neurosci.12, 2464. Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.
Mooney, R. 1992. J. Neurosci.12, 2464. Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
29-June-2018 JSW
Description
A quaternary lidocaine derivative, permanently charged and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.
Form
Lyophilized solid
CAS number
21306-56-9
Chemical formula
C₁₆H₂₇BrN₂O
Structure formula
Purity
≥99%
Biological activity
fully active in neurophysiological testing
Solubility
H₂O (3 mg/ml)
Storage
Protect from light
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.
Toxicity
Irritant
References
Mooney, R. 1992. J. Neurosci.12, 2464. Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.
