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Binds the vesicular monoamine transporter (VMAT2) and acts as an irreversible transport inhibitor of biogenic amines. Used as a long-lasting bioamine depleter. Prevents bioamine transport into synaptic vesicles and chromaffin granules. Used as antihypertensive and antipsychotic drugs.
Oe, T., et al. 2010. Neurosci.169, 1860. Metzger, R. et al. 2002. Eur. J. Pharmacol.456, 39. Heslop, E., et al. 1999. Neuropharmacol.38, 883. Schuldiner, S., et al. 1993. J. Biol. Chem.268, 29.
Oe, T., et al. 2010. Neurosci.169, 1860. Metzger, R. et al. 2002. Eur. J. Pharmacol.456, 39. Heslop, E., et al. 1999. Neuropharmacol.38, 883. Schuldiner, S., et al. 1993. J. Biol. Chem.268, 29.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Binds the vesicular monoamine transporter (VMAT2) and acts as an irreversible transport inhibitor of biogenic amines. Used as a long-lasting bioamine depleter. Prevents bioamine transport into synaptic vesicles and chromaffin granules. Used as antihypertensive and antipsychotic drugs.
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
50-55-5
Chemical formula
C₃₃H₄₀N₂O₉
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (100 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Harmful & Carcinogenic / Teratogenic
References
Oe, T., et al. 2010. Neurosci.169, 1860. Metzger, R. et al. 2002. Eur. J. Pharmacol.456, 39. Heslop, E., et al. 1999. Neuropharmacol.38, 883. Schuldiner, S., et al. 1993. J. Biol. Chem.268, 29.
