573121 Sigma-AldrichSMER28 - CAS 307538-42-7 - Calbiochem
A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo.
More>> A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Less<<SMER28 - CAS 307538-42-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: (6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 307538-42-7 | C₁₁H₁₀BrN₃ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
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| 573121-10MGCN |
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塑胶安瓿;塑胶针药瓶 | 10 mg |
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| Description | |
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| Overview | A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR. |
| Catalogue Number | 573121 |
| Brand Family | Calbiochem® |
| Synonyms | (6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II |
| References | |
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| References | Tian, Y., et al. 2011. FASEB J. 25, 1934. Sarkar, S., et al. 2007. Nat. Chem. Biol. 3, 331. |
| Product Information | |
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| CAS number | 307538-42-7 |
| Form | Pale yellow solid |
| Hill Formula | C₁₁H₁₀BrN₃ |
| Chemical formula | C₁₁H₁₀BrN₃ |
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| Quality Level | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 573121-10MGCN | 04055977266054 |
Documentation
SMER28 - CAS 307538-42-7 - Calbiochem MSDS
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SMER28 - CAS 307538-42-7 - Calbiochem 分析证书
| 标题 | 批号 |
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| 573121 |
参考
| 参考信息概述 |
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| Tian, Y., et al. 2011. FASEB J. 25, 1934. Sarkar, S., et al. 2007. Nat. Chem. Biol. 3, 331. |