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572650 Sigma-AldrichSU9516 - CAS 666837-93-0 - Calbiochem

A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells.

SU9516 - CAS 666837-93-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one

Primary Target: Cdk2/A

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
666837-93-0	C₁₃H₁₁N₃O₂

价格及供货情况

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Description
Overview	A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks; IC₅₀ = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). It shows no significant effect (IC₅₀ >10 µM) on the activities of PKC, p38, PDGFRβ, or EGFR. Inhibits the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
Catalogue Number	572650
Brand Family	Calbiochem®
Synonyms	3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one

References
References	Yu, B., et al. 2002. Biochem. Pharmacol. 64, 1091. Lane, M.E., et al. 2001. Cancer Res. 61, 6170.

Product Information
CAS number	666837-93-0
ATP Competitive	Y
Form	Yellow to orange solid
Hill Formula	C₁₃H₁₁N₃O₂
Chemical formula	C₁₃H₁₁N₃O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Cdk2/A
Primary Target IC<sub>50</sub>	22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
572650-5MGCN	04055977266313

Documentation

SU9516 - CAS 666837-93-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

SU9516 - CAS 666837-93-0 - Calbiochem 分析证书

标题	批号
572650	输入批号

参考

参考信息概述
Yu, B., et al. 2002. Biochem. Pharmacol. 64, 1091. Lane, M.E., et al. 2001. Cancer Res. 61, 6170.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-December-2018 JSW
Synonyms	3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
Description	A cell-permeable, 3-substituted indolinone compound that displays anti-proliferative and pro-apoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks) (IC₅₀ = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). Exhibits no significant effect on the activities of PKC, p38, PDGFRβ, or EGFR (IC₅₀ >10 µM). Reported to inhibit the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
Form	Yellow to orange solid
CAS number	666837-93-0
Chemical formula	C₁₃H₁₁N₃O₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Yu, B., et al. 2002. Biochem. Pharmacol. 64, 1091. Lane, M.E., et al. 2001. Cancer Res. 61, 6170.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors

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