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648492 Sigma-AldrichTRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem

The TRPM4 inhibitor, 9-Phenanthrol, also referenced under CAS 484-17-3, controls the biological activity of TRPM4. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Phenanthren-9-ol, 9-Hydroxyphenanthrene

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
484-17-3	C₁₄H₁₀O

价格及供货情况

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Description
Overview	A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC₅₀ = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
Catalogue Number	648492
Brand Family	Calbiochem®
Synonyms	Phenanthren-9-ol, 9-Hydroxyphenanthrene

References
References	Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697. Simard, C., 2012. Brit. Journ. Pharm.165, 2354.

Product Information
CAS number	484-17-3
Form	Brown solid
Hill Formula	C₁₄H₁₀O
Chemical formula	C₁₄H₁₀O
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
648492-50MGCN	04055977185072

Documentation

TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem 分析证书

标题	批号
648492	输入批号

参考

参考信息概述
Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697. Simard, C., 2012. Brit. Journ. Pharm.165, 2354.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-July-2012 JSW
Synonyms	Phenanthren-9-ol, 9-Hydroxyphenanthrene
Description	A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC₅₀ = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
Form	Brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	484-17-3
Chemical formula	C₁₄H₁₀O
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697. Simard, C., 2012. Brit. Journ. Pharm.165, 2354.

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Life Science Relevant Organics and Inorganics > TRP Channels

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