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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

676496 Sigma-AldrichVEGF Inhibitor, CBO-P11 - Calbiochem

VEGF Inhibitor, CBO-P11, is a macrocyclic peptide derived from residues 79-93 of VEGF. Mediates VEGF binding to VEGFR-2. Blocks VEGF165 binding to VEGFR1 and 2 (IC50 = 700 nM & 1.3 µM, respectively).

VEGF Inhibitor, CBO-P11 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: Cyclo-VEGI, cyclic(D-F-PQIMRIKPHQGQHIGE), D-Phe-Pro(79-93), VEGFR Tyrosine Kinase Inhibitor XX, VEGFR2 Kinase Inhibitor XVI

Primary Target: Blocks the binding of VEGF165 to its receptors

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概述

Replacement Information

重要规格表

Empirical Formula
C₉₀H₁₄₀N₂₈O₂₂S

价格及供货情况

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Description
Overview	A macrocyclic 17-amino acid peptide derived from residues 79 - 93 of vascular endothelial growth factor that mediate its binding to VEGFR-2. It blocks the binding of VEGF₁₆₅ to its receptors (IC₅₀ = 700 nM for VEGFR1, 1.3 µM for VEGFR2) and exhibits anti-angiogenic activity as well as other VEGFR-mediated cellular functions, such as proliferation (IC₅₀ = 5.8 µM), migration (IC₅₀ = 8.2 µM), and activation of MAP kinases. Its anti-angiogenic activity has been successfully demonstrated in vivo using chick embryos and nude mice tumor models of human intracranial and syngeneic glioma.
Catalogue Number	676496
Brand Family	Calbiochem®
Synonyms	Cyclo-VEGI, cyclic(D-F-PQIMRIKPHQGQHIGE), D-Phe-Pro(79-93), VEGFR Tyrosine Kinase Inhibitor XX, VEGFR2 Kinase Inhibitor XVI

References
References	Zilberberg, L., et al. 2003. J. Biol. Chem. 278, 35564.

Product Information
ATP Competitive	N
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₉₀H₁₄₀N₂₈O₂₂S
Chemical formula	C₉₀H₁₄₀N₂₈O₂₂S
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications
Application	VEGF Inhibitor, CBO-P11, is a macrocyclic peptide derived from residues 79-93 of VEGF. Mediates VEGF binding to VEGFR-2. Blocks VEGF165 binding to VEGFR1 and 2 (IC50 = 700 nM & 1.3 µM, respectively).

Biological Information
Primary Target	Blocks the binding of VEGF165 to its receptors
Primary Target IC<sub>50</sub>	700 nM for VEGFR1, 1.3 µM for VEGFR2
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	cyclic(D-Phe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
676496-1MGCN	04055977260489

Documentation

VEGF Inhibitor, CBO-P11 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

VEGF Inhibitor, CBO-P11 - Calbiochem 分析证书

标题	批号
676496	输入批号

参考

参考信息概述
Zilberberg, L., et al. 2003. J. Biol. Chem. 278, 35564.

引用

标题

Vivian Y. Shin, et al. (2005) Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Molecular Cancer Research 3, 607-615.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-September-2008 RFH
Synonyms	Cyclo-VEGI, cyclic(D-F-PQIMRIKPHQGQHIGE), D-Phe-Pro(79-93), VEGFR Tyrosine Kinase Inhibitor XX, VEGFR2 Kinase Inhibitor XVI
Description	A macrocyclic, 17-amino acid peptide derived from residues 79-93 of vascular endothelial growth factor (VEGF) that mediates the binding of VEGF to its receptor, VEGFR-2. Blocks the binding of VEGF₁₆₅ to its receptors (IC₅₀ = 70 nM for VEGFR-1, 1.3 µM for VEGFR-2) and exhibits anti-angiogenic properties. Also reported to block other VEGF-mediated cellular functions such as proliferation (IC₅₀ = 5.8 µM), migration (IC₅₀ = 8.2 µM), and activation of MAP kinases. Also reported to exhibit anti-angiogenic properties in vivo using chick embryo and nude mouse tumor models of human intracranial and syngeneic glioma.
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₉₀H₁₄₀N₂₈O₂₂S
Peptide Sequence	cyclic(D-Phe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu)
Purity	≥97% by HPLC
Solubility	DMSO (5 mg/ml) or H₂O
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Zilberberg, L., et al. 2003. J. Biol. Chem. 278, 35564.
Citation	Vivian Y. Shin, et al. (2005) Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Molecular Cancer Research 3, 607-615.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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