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681671 Sigma-AldrichWnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem

Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
686770-61-6	C₂₂H₁₈N₄O₂S₃

价格及供货情况

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Description
Overview	A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072).
Catalogue Number	681671
Brand Family	Calbiochem®
Synonyms	Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I

References
References	Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.

Product Information
CAS number	686770-61-6
Form	Off-white solid
Hill Formula	C₂₂H₁₈N₄O₂S₃
Chemical formula	C₂₂H₁₈N₄O₂S₃
Quality Level	MQ100

Applications
Application	Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
S Phrase	S: 22-24/25-36-45 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
681671-10MGCN	04055977225198

Documentation

Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem 分析证书

标题	批号
681671	输入批号

参考

参考信息概述
Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-February-2014 JSW
Synonyms	Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I
Description	A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	686770-61-6
Chemical formula	C₂₂H₁₈N₄O₂S₃
Purity	≥97% by HPLC
Solubility	DMSO (2.5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful
References	Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology > Wnt Signaling Inhibitors

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