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506163 Sigma-Aldrichp38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem

The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
321351-00-2	C₂₀H₁₆BrClN₂O

价格及供货情况

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Description
Overview	A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β₂ (82% and 93% inhibition with 1 µM inhibitor, respectively; IC₅₀ of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
Catalogue Number	506163
Brand Family	Calbiochem®
Synonyms	(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone

References
References	Ottosen, E.R., et al. 2003. J. Med. Chem. 46, 5651.

Product Information
CAS number	321351-00-2
Form	Yellow solid
Hill Formula	C₂₀H₁₆BrClN₂O
Chemical formula	C₂₀H₁₆BrClN₂O
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
S Phrase	S: 22-24/25-36/37/39-45 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
506163-5MGCN	04055977272307

Documentation

p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem 分析证书

标题	批号
506163	输入批号

参考

参考信息概述
Ottosen, E.R., et al. 2003. J. Med. Chem. 46, 5651.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	15-April-2009 RFH
Synonyms	(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
Description	A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β₂ (82% and 93% inhibition with 1 µM inhibitor, respectively; IC₅₀ of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	321351-00-2
Chemical formula	C₂₀H₁₆BrClN₂O
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (50 mg/ml) or Ethanol (15 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Ottosen, E.R., et al. 2003. J. Med. Chem. 46, 5651.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

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