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506170 p53-Snail binding Inhibitor, GN25 - Calbiochem

概述

Replacement Information

重要规格表

Empirical Formula
C₁₅H₁₄O₆S

价格及供货情况

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506170-25MGCN
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      玻璃瓶 25 mg
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      Description
      OverviewA cell-permeable, water soluble and specific p53-Snail binding inhibitor that activates p53 in a K-Ras-dependent manner and displays anti-proliferating effect toward K-Ras-MEF (K-Ras-transformed mouse embryonic fibroblast) cells with 20% viability at 10µM, but not in N-Ras/Myc-MEF or non-transformed MEF. Snail and p53 expression are elevated in a dose dependent manner after GN25 treatment at 1-10µM in K-Ras-mutated human cancer cell lines A549, but not in MKN-45 (wt-K-Ras/wt-p53) cells. Furthermore, it is shown to selectively activate wild-type p53 in p53WT/MT cancer cells, but not Panc-1 cells with single allelic mutant p53. Exhibits anti-tumor effect in a xenograft model in vivo.
      Catalogue Number506170
      Brand Family Calbiochem®
      SynonymsGN25
      References
      ReferencesLee, S., et al. 2010. Oncogene 29, 4576.
      Product Information
      FormOrange powder
      Hill FormulaC₁₅H₁₄O₆S
      Chemical formulaC₁₅H₁₄O₆S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      506170-25MGCN 04055977272369

      Documentation

      p53-Snail binding Inhibitor, GN25 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      p53-Snail binding Inhibitor, GN25 - Calbiochem 分析证书

      标题批号
      506170

      参考

      参考信息概述
      Lee, S., et al. 2010. Oncogene 29, 4576.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-February-2011 RFH
      SynonymsGN25
      DescriptionA cell-permeable, water soluble and specific p53-Snail binding inhibitor that activates p53 in a K-Ras-dependent manner and displays anti-proliferating effect toward K-Ras-MEF (K-Ras-transformed mouse embryonic fibroblast) cells with 20% viability at 10µM, but not in N-Ras/Myc-MEF or non-transformed MEF. Snail and p53 expression are elevated in a dose dependent manner after GN25 treatment at 1-10µM in K-Ras-mutated human cancer cell lines A549, but not in MKN-45 (wt-K-Ras/wt-p53) cells. Furthermore, it is shown to selectively activate wild-type p53 in p53WT/MT cancer cells, but not Panc-1 cells with single allelic mutant p53. Exhibits anti-tumor effect in a xenograft model in vivo.
      FormOrange powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₁₄O₆S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, S., et al. 2010. Oncogene 29, 4576.