Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
Methylation as a part of signal transduction is carried out by methyltransferase enzymes that reversibly add methyl groups to the carboxyl groups of proteins and DNA, forming methyl esters.
Cell signaling pathways transmit the reactions of cells to various internal and external stimuli. Intracellular signal transduction is often accomplished through a series of reversible protein phosphorylation events.
Protein phosphorylation systems are composed of at least three components: (a) phosphoproteins (b) kinases and (c) phosphatases, that dephosphorylate the phosphoproteins, thereby restoring the system to its basal stage.
Histone peptide arrays are essential screening tools to evaluate the specificity and cross-reactivity of antibodies against histones H2A, H2B, H3, H4, and their post-translational modifications.The arrays are designed on PVDF membranes for a simple Western blot-like assay.
Antibodies and assays are offered with breadth and depth in major research areas: Neuroscience, Epigenetics, Cell Signaling, Cancer and Cell Structure, backed by excellent service and support.
Cytoplasmic signaling proteins play crucial roles in cell cycle, targeted proteolysis, protein trafficking, cytoskeletal organization, and gene expression.
Extracellular cell signaling is triggered inside the cell trough by binding molecules, such as hormones, pharmacophores, toxins, or neurotransmitters, to the extracellular domains of transmembrane receptors.
Post-translational modifications (PTM) affect signaling proteins which makes the study of cell signaling pathways challenging. Our technologies for signaling research, combined with validated antibodies for proteins and PTMs, enable you to choose the perfect assay.