5.05736
5-BDBD
Synonym(s):
5-BDBD, 5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
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About This Item
Empirical Formula (Hill Notation):
C17H11BrN2O2
CAS Number:
Molecular Weight:
355.19
UNSPSC Code:
12352200
MDL number:
Assay:
≥99% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
powder
potency
500 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 15 mg/mL
storage temp.
2-8°C
InChI
1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)
InChI key
NKYMVQPXXTZHSF-UHFFFAOYSA-N
General description
A highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.
Biochem/physiol Actions
Primary Target
P2X₄
P2X₄
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Trabanelli, S., et al. 2012. J. Immunol.189, 1303.
Wu, T., et al. 2011. Am. J. Physiol.301, H69.
Wu, T., et al. 2011. Am. J. Physiol.301, H69.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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