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5.06135

Venlafaxine Hydrochloride

Name: Venlafaxine Hydrochloride
Brand: MM

Synonym(s):

Venlafaxine Hydrochloride, SERT/NET Inhibitor, Venlafaxine, Serotonin-norepinephrine Inhibitor, Venlafaxien

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₇NO₂ · xHCl

CAS Number:

99300-78-4

Molecular Weight:

277.40 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD03658865

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥99% (HPLC)

Quality Segment

100

form

solid

potency

82 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 100 mM, DMSO: 50 mM

storage temp.

2-8°C

SMILES string

[Cl-].N(CC(C2(CCCCC2)O)c1ccc(cc1)OC)(C)C.[H+]

InChI

1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

InChI key

QYRYFNHXARDNFZ-UHFFFAOYSA-N

Description

General description

A dual reuptake inhibitor of serotonin-norepinephrine with strong preference to serotonin (K_i = 82 and 2480 nM for SERT and NET respectively). Also inhibits reuptake of dopamine. Used in studies of depression, ADHD, and stress-related anxiety.

Biochem/physiol Actions

Primary Target
SERT/NET

Packaging

Packaged under inert gas

Other Notes

Kaur, J., et al. et al. 2010. J. Pharmacy & Bioallied Sci.2, 22.

Aboelwafa, A., et al. 2010. AAPS PharmSciTech.11, 1026.
Bernardi, S., et al. 2009. J. Thermal Analysis & Calorimetry.97, 729.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Hazard Classifications

Aquatic Chronic 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c