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M5273

Monensin sodium salt

Name: Monensin sodium salt
Brand: SIGMA

90-95% (TLC), Sodium ionophore

동의어(들):

Monensin A sodium salt

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₃₆H₆₁NaO₁₁

CAS 번호:

22373-78-0

Molecular Weight:

692.85

NACRES:

NA.77

PubChem Substance ID:

24896992

UNSPSC Code:

12352200

EC Number:

244-941-7

MDL number:

MFCD00077826

Beilstein/REAXYS Number:

4122200

Assay:

90-95% (TLC)

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속성

제품 이름

Monensin sodium salt, 90-95% (TLC)

Quality Segment

200

assay

90-95% (TLC)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi, parasites, viruses

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

[H][C@]1([C@@]2(CC)O[C@]([C@@]3(C)OC4(C[C@H](O)[C@@H](C)[C@@]([H])([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)O4)CC3)([H])CC2)[C@@H](C)C[C@]([H])([C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C)O1.[Na+]

InChI

1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35?,36-;/m0./s1

InChI key

XOIQMTLWECTKJL-BEMBKCOJSA-M

설명

General description

Chemical structure: polyether

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis in poultry production.

Application

Monensin sodium salt has been used:

for the intracellular staining of cytokines
to study its effects on the regulation of nuclear factor-κ B (NF-κB ) activation
as a positive control to study its effects on in vitro rumen fermentation

Biochem/physiol Actions

Na⁺ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

pictograms

GHS06,GHS08,GHS09

signalword

Danger

hcodes

H300,H319,H373,H411

pcodes

P260 - P264 - P273 - P301 + P310 - P305 + P351 + P338 - P314

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2

target_organs

Heart,muscle

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c