196878 (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem

Synthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester

Primary Target: L-type Ca2+ channel
196878
Árak és elérhetőség megtekintése

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical FormulaCAS #
C₁₆H₁₅F₃N₂O₄ 93468-89-4

Árak és elérhetőség

Katalógusszám ElérhetőségCsomagolás Menny./csomag Ár Mennyiség
196878-1MG
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      		 Muanyagampulla 1 mg
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      Elmentette a ()-t
       
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      196878-5MG
      Elérhetőség betöltése...
      —
      Korlátozott elérhetőségKorlátozott elérhetőség
      Készleten 
      Megszűnt
      Korlátozott mennyiségben elérhető
      Az elérhetőség megerősítésre vár
        Remaining : Will advise
          Remaining : Will advise
          Tanácsadás
          Lépjen kapcsolatba a vevőszolgálattal
          Contact Customer Service

          		 Muanyagampulla 5 mg
          Az ár letöltése folyamatban...
          Az ár nem tölthető be
          Minimum Quantity needs to be mulitiple of
          Megrendelés befejezésekor További információ
          Elmentette a ()-t
           
          —
          Árajánlat kérése
          		 —
          Description
          OverviewSynthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
          Catalogue Number196878
          Brand Family Calbiochem®
          Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
          References
          ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
          Product Information
          CAS number93468-89-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₆H₁₅F₃N₂O₄
          Chemical formulaC₁₆H₁₅F₃N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetL-type Ca2+ channel
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          196878

          References

          Hivatkozások áttekintése
          Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-February-2009 JSW
          Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
          DescriptionA synthetic dihydropyridine derivative that is an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
          FormYellow solid
          CAS number93468-89-4
          Chemical formulaC₁₆H₁₅F₃N₂O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol (35 mg/ml) or DMSO (35 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
          Toxicity Irritant
          ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
          Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
          Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
          Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
          Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
          Tagliatela, M., et al. 1986. Brain Res. 381, 356.
          Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.